Publications

Publications till june 2016

Acknowdlegement Psychaid Project:

  • Haarman BC, Burger H, Doorduin J, Renken RJ, Sibeijn-Kuiper AJ, Marsman JC, de Vries EF, de Groot JC, Drexhage HA, Mendes R, Nolen WA, Riemersma-Van der Lek RF. Corrigendum to “Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder – A combined magnetic resonance imaging and positron emission tomography study” [Brain Behav. Immun. (2015)].Brain Behav Immun. 2016 Jun 13.
  • Massolt ET, Effraimidis G, Korevaar TI, Wiersinga WM, Visser WE, Peeters RP, Drexhage HA. Aberrant Levels of Hematopoietic/Neuronal Growth and Differentiation Factors in Euthyroid Women at Risk for Autoimmune Thyroid Disease. PLoS One. 2016 Apr 19;11(4):e0153892. doi:10.1371/journal.pone.0153892. eCollection 2016.
  • Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB. Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia. Schizophr Bull. 2016;42(2):386-95. doi: 10.1093/schbul/sbv134.
  • Tomasik J, Schwarz E, Lago SG, Rothermundt M, Leweke FM, van Beveren NJ, Guest PC, Rahmoune H, Steiner J, Bahn S. Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients. Brain Behav Immun. 2016;52:178-86. doi: 10.1016/j.bbi.2015.10.019.
  • Ruland T, Chan MK, Stocki P, Grosse L, Rothermundt M, Cooper JD, Arolt V, Bahn S. Molecular serum signature of treatment resistant depression. Psychopharmacology (Berl). 2016 Jun 20. [Epub ahead of print] PubMed PMID: 27325393.
  • Snijders G, Schiweck C, Mesman E, Grosse L, De Wit H, Nolen WA, Drexhage HA, Hillegers MH. A dynamic course of T cell defects in individuals at risk for mood disorders. Brain Behav Immun. 2016 May 12. pii: S0889-1591(16)30116- 7. doi: 10.1016/j.bbi.2016.05.007. [Epub ahead of print] PubMed PMID: 27181178.
  • Grosse L, Carvalho LA, Birkenhager TK, Hoogendijk WJ, Kushner SA, Drexhage HA, Bergink V. Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy. Psychopharmacology (Berl). 2016 May;233(9):1679-88. doi: 10.1007/s00213-015- 3943-9. Epub 2015 May 8. PubMed PMID: 25953327.
  • Grosse L, Hoogenboezem T, Ambrée O, Bellingrath S, Jörgens S, de Wit HJ, Wijkhuijs AM, Arolt V, Drexhage HA. Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation. Brain Behav Immun. 2016 May;54:38-44. doi: 10.1016/j.bbi.2015.12.003. Epub 2015 Dec 8. PubMed PMID: 26674997.
  • Grosse L, Carvalho LA, Wijkhuijs AJ, Bellingrath S, Ruland T, Ambrée O, Alferink J, Ehring T, Drexhage HA, Arolt V. Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder. Brain Behav Immun. 2015 Feb;44:48-56. doi: 10.1016/j.bbi.2014.08.004. Epub 2014 Aug 20. PubMed PMID: 25150007.
  • Becking K, Haarman BC, van der Lek RF, Grosse L, Nolen WA, Claes S, Drexhage HA, Schoevers RA. Inflammatory monocyte gene expression: trait or state marker in bipolar disorder? Int J Bipolar Disord. 2015 Dec;3(1):20. doi: 10.1186/s40345-015- 0037-x. Epub 2015 Sep 17. PubMed PMID: 26381439; PubMed Central PMCID: PMC4574035.
  • Ambrée O, Bergink V, Grosse L, Alferink J, Drexhage HA, Rothermundt M, Arolt V, Birkenhäger TK. S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression. Int J Neuropsychopharmacol. 2015 Sep 12;19(3). pii: pyv103. doi: 10.1093/ijnp/pyv103. PubMed PMID: 26364276; PubMed Central PMCID: PMC4815471.
  • Tomasik J, Yolken RH, Bahn S, Dickerson FB. Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: A Randomized, Placebo-Controlled Trial. Biomark Insights. 2015;10:47-54. doi: 10.4137/BMI.S22007.
  • Mesman E, Hillegers MH, Ambree O, Arolt V, Nolen WA, Drexhage HA. Monocyte activation, brain-derived neurotrophic factor (BDNF), and S100B in bipolar offspring: a follow-up study from adolescence into adulthood. Bipolar Disord. 2015 Feb;17(1):39-49.
  • Haarman BC, Riemersma-Van der Lek RF, Nolen WA, Mendes R, Drexhage HA, Burger H. Feature- expression heat maps – A new visual method to explore complex associations between two variable sets. J Biomed Inform. 2014 Oct 14. [Epub ahead of print]
  • Tomasik J, Rahmoune H, Guest PC, Bahn S. Neuroimmune biomarkers in schizophrenia. Schizophr Res. 2014 Aug 11. pii: S0920-9964(14)00382- X. doi: 10.1016/j.schres.2014.07.025. [Epub ahead of print] Review. PMID: 25124519
  • Chan MK, Gottschalk MG, Haenisch F, Tomasik J, Ruland T, Rahmoune H, Guest PC, Bahn S. Applications of blood-based protein biomarker strategies in the study of psychiatric disorders. Prog Neurobiol. 2014 Nov;122:45-72. doi: 10.1016/j.pneurobio.2014.08.002. Epub 2014 Aug 27. PMID: 25173695 [PubMed - in process]
  • Gos T, Myint AM, Schiltz K, Meyer-Lotz G, Dobrowolny H, Busse S, Müller UJ, Mawrin C, Bernstein HG, Bogerts B, Steiner J. “Reduced microglial immunoreactivity for endogenous NMDA receptor agonist quinolinic acid in the hippocampus of schizophrenia patients” Brain Behav Immun. 2014 Jun 2. pii: S0889-1591(14)00134- 2. doi: 10.1016/j.bbi.2014.05.012. [Epub ahead of print] PubMed PMID:24886967.
  • Myint AM, Kim YK. “Network beyond IDO in psychiatric disorders: revisiting neurodegeneration hypothesis” Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:304-13. doi: 10.1016/j.pnpbp.2013.08.008. Epub 2013 Oct 31. PubMed PMID: 24184687.

In relation to the Psychaid Project;

  • Bahn S, Chan MK. What can we learn about depression from gene expression in peripheral tissues? Biol Psychiatry. 2015 Feb 1;77(3):207-9.
  • Bergink V, Gibney SM, Drexhage HA. Autoimmunity, inflammation, and psychosis: a search for peripheral markers. Biol Psychiatry. 2014 Feb 15;75(4):324-31. Review.
  • Bergink V, Burgerhout KM, Weigelt K, Pop VJ, de Wit H, Drexhage RC, Kushner SA, Drexhage HA. Immune system dysregulation in first-onset postpartum psychosis. Biol Psychiatry. 2013 May 15;73(10):1000-7.
  • Beumer W, Effraimidis G, Drexhage RC, Wiersinga WM, Drexhage HA. Changes in serum adhesion molecules, chemokines, cytokines, and tissue remodeling factors in euthyroid women without thyroid antibodies who are at risk for autoimmune thyroid disease: a hypothesis on the early phases of the endocrine autoimmune reaction. J Clin Endocrinol Metab. 2013 Jun;98(6):2460-8.
  • Beumer W, Gibney SM, Drexhage RC, Pont-Lezica L, Doorduin J, Klein HC, Steiner J, Connor TJ, Harkin A, Versnel MA, Drexhage HA. The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes. J Leukoc Biol. 2012 Nov;92(5):959-75. Review.
  • Beumer W, Drexhage RC, De Wit H, Versnel MA, Drexhage HA, Cohen D. Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome. Psychoneuroendocrinology. 2012 Dec;37(12):1901-11.
  • Broek JA, Guest PC, Rahmoune H, Bahn S. Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins. Mol Autism. 2014 Jul 30;5:41
  • Broek JA, Brombacher E, Stelzhammer V, Guest PC, Rahmoune H, Bahn S. The need for a comprehensive molecular characterization of autism spectrum disorders. Int J Neuropsychopharmacol. 2014 Apr;17(4):651-73.
  • Carvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK, Drexhage HA. Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder. Transl Psychiatry. 2014 Jan 14;4:e344.
  • Gibney SM, Drexhage HA. Evidence for a dysregulated immune system in the etiology of psychiatric disorders. J Neuroimmune Pharmacol. 2013 Sep;8(4):900-20. Review.
  • Guest PC, Chan MK, Gottschalk MG, Bahn S. The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patients. Biomark Med. 2014;8(1):15-27. Review.
  • Haarman BC, Riemersma-Van der Lek RF, Nolen WA, Mendes R, Drexhage HA, Burger H. Feature-expression heat maps – A new visual method to explore complex associations between two variable sets. J Biomed Inform. 2014 Oct 14. [Epub ahead of print]
  • Haarman BC, Riemersma-Van der Lek RF, de Groot JC, Ruhé HG, Klein HC, Zandstra TE, Burger H, Schoevers RA, de Vries EF, Drexhage HA, Nolen WA, Doorduin J. Neuroinflammation in bipolar disorder – A [(11)C]-(R)-PK11195 positron emission tomography study. Brain Behav Immun. 2014 Aug;40:219-25.
  • Haarman BC, Riemersma-Van der Lek RF, Burger H, Netkova M, Drexhage RC, Bootsman F, Mesman E, Hillegers MH, Spijker AT, Hoencamp E, Drexhage HA, Nolen WA. Relationship between clinical features and inflammation-related monocyte gene expression in bipolar disorder – towards a better understanding of psychoimmunological interactions. Bipolar Disord. 2014 Mar;16(2):137-50.
  • Krause D, Jobst A, Kirchberg F, Kieper S, Härtl K, Kästner R, Myint AM, Müller N, Schwarz MJ. Prenatal immunologic predictors of postpartum depressive symptoms: a prospective study for potential diagnostic markers. Eur Arch Psychiatry Clin Neurosci. 2014 Oct;264(7):615-24.
  • Krause D, Weidinger E, Dippel C, Riedel M, Schwarz MJ, Müller N, Myint AM. Impact of different antipsychotics on cytokines and tryptophan metabolites in stimulated cultures from patients with schizophrenia. Psychiatr Danub. 2013 Dec;25(4):389-97.
  • Mesman E, Hillegers MH, Ambree O, Arolt V, Nolen WA, Drexhage HA. Monocyte activation, brain-derived neurotrophic factor (BDNF), and S100B in bipolar offspring: a follow-up study from adolescence into adulthood. Bipolar Disord. 2015 Feb;17(1):39-49.
  • Müller N, Myint AM, Schwarz MJ. Inflammation in schizophrenia. Adv Protein Chem Struct Biol. 2012;88:49-68. Review.
  • Müller N, Myint AM, Schwarz MJ. Immunological treatment options for schizophrenia. Curr Pharm Biotechnol. 2012 Jun;13(8):1606-13. Review.
  • Myint AM. Immuno-neuroendocrino-neurochemical interaction in psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:259-60.
  • Myint AM, Bondy B, Baghai TC, Eser D, Nothdurfter C, Schüle C, Zill P, Müller N, Rupprecht R, Schwarz MJ. Tryptophan metabolism and immunogenetics in major depression: a role for interferon-γ gene. Brain Behav Immun. 2013 Jul;31:128-33.
  • Myint AM. Inflammation, neurotoxins and psychiatric disorders. Mod Trends Pharmacopsychiatri. 2013;28:61-74. Review
  • Pujol Lopez Y, Steinbusch HW, Rutten B, Kenis G, van den Hove DL, Myint AM. Effects of Subcutaneous LPS Injection on Gestational Length and Intrauterine and Neonatal Mortality in Mice. Neuroimmunomodulation. 2015 Jan 22. [Epub ahead of print]
  • Ramsey JM, Schwarz E, Guest PC, van Beveren NJ, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Bahn S. Distinct molecular phenotypes in male and female schizophrenia patient. PLoS One. 2013 Nov 11;8(11):e78729.
  • Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S. Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome. Mol Autism. 2014 Jan 27;5(1):4.
  • van Beveren NJ, Schwarz E, Noll R, Guest PC, Meijer C, de Haan L, Bahn S. Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia. Transl Psychiatry. 2014 Aug 26;4:e430.
  • Weigelt K, Bergink V, Burgerhout KM, Pescatori M, Wijkhuijs A, Drexhage HA. Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis. Brain Behav Immun. 2013 Mar;29:147-55.
  • de Witte L, Tomasik J, Schwarz E, Guest PC, Rahmoune H, Kahn RS, Bahn S. Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatment. Schizophr Res. 2014 Apr;154(1-3):23-9.